Hydrotropic Solubilization. Priyanka Arjaria1, Manoj Goyal2, Suman Jain3. 1Shri Ram College of pharmacy,Banmore,Morena, India, 2IPS College of pharmacy. Purpose. This study examines the mechanism of hydrotropic solubilization using the riboflavin-nicotinamide system. The most commonly proposed mechanism. On the other hand, planarity of the hydrophobic part has been emphasized as an important factor in the mechanism of hydrotropic solubilization. Solute consists.

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The results of qualitative solubility of Lumefantrine shown in Table solubilizatiion reveal that the drug is freely soluble in dichloromethane, ethyl acetate and chloroform. The value of LOD was 0.

Hydrotrope – Wikipedia

Mixed hydrotropy in spectrophotometric analysis of poorly water-soluble drug. The solhbilization are thankful for Gokula Education Foundation for providing necessary facilities to carry out the research work. Solubility indicates the maximum amount of a substance that can be dissolved in a solvent at a given temperature. Solubility enhancement of ibuprofen using hydrotropic agents.

The study revealed that estimations of lornoxicam can be done within 24 hours without any detrimental effect on drug stability as no precipitation was observed. It depends upon the nature of solubilizatiln solute and accuracy of the method employed.

Application of mixed- hydrotropy to develop injection dosage forms of poorly water-soluble drugs. New quantitative estimation of benzoic acid bulk sample using calcium disodium edetate as hydrotropic solubilizing agent.

R K Maheshwari, Mithun Singh Rajput, Sampada Sinha[23] were developed titrimetric analysis method to solubilize the slightly water soluble topical antifungal drug, benzoic acid by 1. Most of the previous methods employed have used organic solvents or hydrotropes such as sodium lauryl sulphate and urea to increase aqueous solubility of lornoxicam [ 45 ]. The process of solubilisation involves the breaking of inter-ionic or intermolecular bonds in the solute, solubilizatioh separation of the molecules of the solvent to provide space in the solvent for the solute, interaction between the solvent and the solute molecule or ion.


In order to check the accuracy and reproducibility of the proposed method, recovery studies were conducted. Hydrotropy is one of the solubility enhancement techniques which enhance solubility to many folds with use of hydrotropes like hydrotrolic benzoate, sodium solubiliztion, urea, niacinamide etc.


The absorbances were recorded against respective reagent blanks at appropriate wavelengths. Repeatability results indicated the precision under the same operating conditions over a short interval of time and interassay precision. Solubility enhancement of theophylline drug using different solubilization techniques.

A Promising tool for solubility Enhancement”, Int J. Typically, hydrotropes consist of a hydrophilic part and a hydrophobic part like surfactants but the hydrophobic part is generally sklubilization small to cause spontaneous self-aggregation. If exact solubilities are not known, the pharmacopoeia provides general terms to describe a given range.

Views Read Edit View history. The pH dependent solubility of Lumefantrine in different phosphate buffers ranging from pH 1. Solubility can be enhanced by many techniques among them hydrotropy is of very much importance.

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View at Google Scholar Y. Hydrotropes are a class of chemical compounds which affect an increased aqueous solubility by several folds to certain solutes which are sparingly soluble in water under normal conditions.

Aggregate exposures to consumers direct and indirect dermal contact, ingestion, and inhalation have been estimated to be 1. Therapeutic efficacy of a drug depends upon its bioavailability and ultimately its solubility to achieve a desired concentration in systemic solybilization.


A saturated solution is one in which the solute is soulbilization equilibrium with the solvent[]. Preparation of hydrotropic solid dispersions of poorly water-soluble drugs precluding the use of organic solvents. An excess quantity of drug was added to a series of stoppered conical flasks containing 10 ml of phosphate buffer solutions of varying pH until saturated solution was obtained.

Accuracy and reproducibility of the proposed method were further hyfrotropic by recovery studies. International Journal of Pharmaceutics ; An excess quantity of drug was added to a series of stoppered conical flasks containing 10 ml of hydrotropic solutions until saturated solution was obtained.

International Scholarly Research Notices

Therapeutic response of drug as well bioavailability can be limited by poor aqueous solubility of drugs. Enhancement of water solubility of felodipine by preparing solid dispersion using poly-ethylene glycol and poly-vinyl alcohol. Novel spectrophotometric quantitative estimation of hydrochlorothiazide in bulk drug and their dosage forms by using hydrotropic agent. This is true for parenterally, topically and orally administered solutions.

It is new, simple, cost-effective, safe, accurate, precise and environmental friendly solubioization for the analysis titrimetric and spectrophotometric of poorly water-soluble drugs titrimetric and spectrophotometric precluding the use of organic solvents.